• The prostate gland contains both malignant and benign cell populations that both contribute to the production of PSA.
• The benign component of PSA is calculated by taking the prostate gland volume and multiplying times 0.066.
• The gland volume is obtained at the time of transrectal ultrasound of the prostate or from an endorectal MRI of the prostate. Less accurate determinations are from a CT scan of the prostate or a digital rectal examination.
• The malignant component equals the total PSA minus the benign component.
• The Gleason score read by an expert is important since the amount of PSA leaked from the prostate cancer into the blood (PSA Leak) is related to the Gleason score.
• The calculated tumor volume is determined by dividing the malignancy-related PSA by the PSA leak for the validated Gleason score.
• A validated Gleason score is one read by an expert in PC pathology. Some of those experts that we have recognized are listed in the PC Address Book on the PCRI website in the Resources section.

Stephen B. Strum, MD
Medical Director of the PCRI
September 2, 2001

Special Note - When using the spread sheet, ONLY modify the yellow cells with your data. All other cells and calculations will be done automatically.

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Download 000PC_Vol_Ver_Strum_2001.xls - Either left mouse click the link or right click the link and choose "Save Target As" or "Save Link As". Note the location where you saved the file. File type is for Microsoft Excel 2000/7.0/97 and other compatible spread sheet programs.

If you have problems downloading the above file in Excel format, try the file below in "zip" format.

Download 000PC_Vol_Ver_Strum_2001.zip - Either left mouse click the link or right click the link and choose "Save Target As" or "Save Link As". Note the location where you saved the file. Contains the file in "zipped" format for easier downloading. File type is for Microsoft Word 2000/7.0/97 and other compatible spread sheet programs.

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