New Clinical Trials for Prostate Cancer

Participation in clinical trials is critical to the approval cycle for new treatments. It is usually the only way a patient can gain access to the latest innovative therapies. While PCRI does not endorse specific trials, we want you to be aware of what’s available. This page includes new clinical trials recently added to www.clinicaltrials.gov, a service of the U.S. National Institutes of Health. For more information on clinical trials, click here:

Added February 11, 2009

An Open Label, Single Arm, Extension Study to Evaluate the Long Term Safety of Denosumab (AMG 162) in the Treatment of Bone Loss in Subjects Undergoing Androgen-Deprivation Therapy for Non-Metastatic Prostate Cancer
NCT00838201 – Phase III – Not yet Recruiting – Location: Contact Amgen

TKI258 in Castrate Resistant Prostate Cancer
NCT00831792 – Phase II – Not yet Recruiting – Location: Houston TX

Health-Related Quality of Life in Gay Men With Localized Prostate Cancer
NCT00828633 – Phase n/a – Currently Recruiting – Location: Phoenix AZ, Houston TX, Toronto Canada

Awareness to Osteopenia's Treatment by Bisphosphonate in Male Suffering From Prostate Cancer (InoPro)
NCT00816452 – Phase n/a – Currently Recruiting – Location: Israel

Salvage Cryotherapy in Recurrent Prostate Cancer (SCORE)
NCT00824928 – Phase n/a – Currently Recruiting – Location: Various in USA

Neoadjuvant Weekly Ixabepilone for High Risk, Clinically Localized Prostate Cancer (BrUOG-Pros-221)
NCT00828308 – Phase II – Currently Recruiting – Location: Providence RI

Characterization of Prostate Cancer With 3T MR
NCT00831142 – Phase n/a – Currently Recruiting – Location: Boston MA

Low-Fat Diet and Omega-Fatty Acids for Prostate Cancer Prevention
NCT00836615 – Phase n/a – Currently Recruiting – Location: Los Angeles CA

Evaluation Ultrasound Elasticity/Tissue Strain-Hardening Imaging for Prostate Cancer Patients Undergoing Radical Prostatectomy
NCT00824902 – Phase n/a – Currently Recruiting – Location: Houston TX

Safety and Efficacy Trial of a RNActive®-Derived Prostate Cancer Vaccine in Hormone Refractory Disease
NCT00831467 – Phase I/II – Currently Recruiting – Location: Several in Germany

Study of Hypofractionated Proton Beam Radiation Therapy for Prostate Cancer
NCT00831623 – Phase I/II – Not yet Recruiting – Location: Loma Linda CA

Exercise in Men With Prostate Cancer
NCT00834392 – Phase n/a – Currently Recruiting – Location: Winnipeg Canada

Symptomatic Study Investigating Degarelix in Patients Suffering From Prostate Cancer
NCT00831233 – Phase III – Not yet Recruiting – Location: Various in Europe

Neoadjuvant Study Investigating Degarelix in Patients Suffering From Prostate Cancer
NCT00833248 – Phase III – Not yet Recruiting – Location: Various in Europe

A Pilot Study to Assess the Follow-up of Prostate Cancer Patients Who Have Undergone Radiotherapy Treatment (PROFUGO)
NCT00823771 – Phase n/a – Currently Recruiting – Location: Geelong Australia

Exercise for Prostate Cancer Patients (EXCAP)
NCT00815672 – Phase n/a – Currently Recruiting – Location: Rochester NY

The Implantation Under Echography of Fiducial Markers in the Intraprostatic Lesion and Prostate
NCT00841685 – Phase n/a – Currently Recruiting – Location: Ghent, Belgium

Study to Evaluate the Safety and Efficacy of Armodafinil Treatment for Patients With Fatigue Associated With Taxane Chemotherapy
NCT00825227 – Phase II – Currently Recruiting – Location: Various in USA

Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel
NCT00824811 – Phase II – Not yet Recruiting – Location: Houston TX

 

Added December 26, 2008

Coping in African American Prostate Cancer Survivors (CAAPS)
NCT00589966 – Phase n/a – Currently Recruiting – Location: Durham NC

Androgen Ablation With or Without Docetaxel in Treating Patients With Advanced Prostate Cancer
NCT00796458 – Phase III – Currently Recruiting – Location: Italy

Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer
NCT00786682 – Phase II – Not yet Recruiting – Location: New Brunswick, New Jersey

Fiducial Localization and Individualized Radiotherapy -Prostate Cancer (FLIP)
NCT00789607 – Phase II – Currently Recruiting – Location: Toronto Canada

Preoperative Docetaxel for Localized Progressive Castration-Resistant Prostate Cancer (CRPC)
NCT00811031 – Phase II – Not yet Recruiting – Location: Houston, Texas

Magnetic Resonance Imaging in Detecting Cancer Progression in Patients With Early Stage Prostate Cancer Undergoing Watchful Waiting
NCT00796874 – Phase n/a – Currently Recruiting – Location: Buffalo, New York

Safety Evaluation of ExAblate MRgFUS (MRI guided Focused Ultrasound) for Prostate Cancer
NCT00811265 – Phase I – Not yet Recruiting – Location: Israel

Biomarker Study of Neoadjuvant Vitamin E in Patients With Locally Treatable Prostate Cancer Prior to Prostatectomy or Brachytherapy
NCT00809458 – Phase III – Currently Recruiting – Location: Albuquerque, New Mexico

Prostate Cancer Support Programs
NCT00798187– Phase n/a – Not yet Recruiting – Location: Houston, Texas

BN83495 in Prostate Cancer (STX64 PC)
NCT00790374 – Phase I – Not yet Recruiting – Location: Baltimore, Maryland

Low-Fat Fish Oil Diet for Prostate Cancer Prevention
NCT00798876 – Phase n/a – Currently Recruiting – Location: Los Angeles, California

Intermittent Treatment With Degarelix of Patients Suffering From Prostate Cancer
NCT00801242 – Phase III – Currently Recruiting – Location: Many in Europe

A Study to Determine the Maximum Tolerated Dose of Elesclomol Sodium Given With a Fixed Dose of Docetaxel and Prednisone in Patients With Metastatic Prostate Cancer
NCT00808418 – Phase I/II – Currently Recruiting – Location: Fountain Valley, California

Clinical Study of SU011248 (sunitinib, Sutent) in Subjects With High Risk Prostate Cancer Who Have Elected to Undergo Radical Prostatectomy
NCT00790595 – Phase I – Currently Recruiting – Location: Los Angeles, California

Study Assessing The Efficacy And Safety Of Avodart (Dutasteride) At Improving Urinary Symptoms In Men With Prostate Cancer Who Are Undergoing Seed Implantation
NCT00805701 – Phase IV – Not yet Recruiting – Location: Not available yet

Biomarker Study for Sunitinib and Docetaxel in Prostate Cancer
NCT00795171 – Phase II – Currently Recruiting – Location: Vienna, Austria

C-11 Choline PET-CT Scan in Finding Metastases in Patients With Newly Diagnosed High-Risk Prostate Cancer
NCT00804245 – Phase n/a – Currently Recruiting – Location: Winston-Salem, North Carolina

Real Time Microscopic Imaging During Robot Assisted Prostate Cancer Surgery
NCT00792961 – Phase n/a – Currently Recruiting – Location: Austin, Texas

Intraprostatic MAXimal Simultaneous Boost
NCT00798837 – Phase I – Not yet Recruiting – Location: Vancouver, Canada

Dasatinib and Bevacizumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot be Removed by Surgery
NCT00792545 – Phase I – Currently Recruiting – Location: Bethesda, Maryland

MRI Targeted Focal Laser Thermal Therapy of Prostate Cancer Followed by Radical Prostatectomy
NCT00805883 – Phase I – Not yet Recruiting – Location: Toronto, Canada

Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate
NCT00809991 – Phase I – Currently Recruiting – Location: Baltimore, Maryland

Salvage Prostatectomy After Radiotherapy
NCT00791115 – Phase n/a – Currently Recruiting – Location: Toronto, Canada

Phase I Targeting Dominant Intraprostatic Lesion Using MR Spectroscopy and HDR Brachytherapy
NCT00807820 – Phase I – Currently Recruiting – Location: San Francisco, California

Retrospective, Non-Interventional Study of Depo-Eligard®. (OCT)
NCT00811876 – Phase n/a – Currently Recruiting – Location: many in Belguim

Change in Penile Length Following Bilateral Nerve-Sparing Radical Prostatectomy
NCT00800813 – Phase n/a – Currently Recruiting – Location: New York, New York

Evaluation of Synthetic Thyrotropin Releasing Hormone (TRH) as a Treatment for Cancer-Related Fatigue
NCT00790296 – Phase II – Currently Recruiting – Location: Farmington, Connecticut

1-Methyl-d-Tryptophan in Treating Patients With Relapsed or Refractory Solid Tumors
NCT00788086 – Phase I – Currently Recruiting – Location: Nashville, Tennessee

Sunitinib and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Chemotherapy
NCT00813423 – Phase I – Not yet Recruiting – Location: New Brunswick, New Jersey

 

Added November 4, 2008

AMG 102 in Combination With Mitoxantrone and Prednisone in Subjects With Previously Treated Castrate Resistant Prostate Cancer
NCT00770848 – Phase I/II – Not yet Recruiting – Location: Contact Amgen

Androgen Ablation Therapy With or Without Vaccine Therapy in Treating Patients With Prostate Cancer
NCT00771017 – Phase II – Not yet Recruiting – Location: Baltimore MD

Gleason Score, Prostate-Specific Antigen Level, and Cancer Stage in Predicting Outcome in Patients Who Have Undergone Radiation Therapy for Localized Prostate Cancer
NCT00769223 – Phase n/a – Currently Recruiting – Location: San Francisco CA

Carbon-11 Acetate PET Scan and MRI in Detecting Cancer in Patients With Localized Prostate Cancer Undergoing Surgery
NCT00771550 – Phase I/II – Currently Recruiting – Location: Bethesda, MD

A Phase I/II Open-Label Study of MCS110 in Patients With Prostate Cancer and Bone Metastases
NCT00757757 – Phase I/II – Currently Recruiting – Location: Las Vegas NV, San Antonio TX

Study of Focal Cryoablation in Low-Risk Prostate Cancer NCT00774436 – Phase II – Currently Recruiting – Location: New York, NY

Goserelin, Flutamine, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer
NCT00767286 – Phase III – Not Recruiting – Location: Philadelphia

White Button Mushroom Extract in Treating Patients With Recurrent Prostate Cancer After Local Therapy
NCT00779168 – Phase I – Currently Recruiting – Location: Duarte CA

Soy Protein in Preventing Recurrent Cancer in Patients Who Have Undergone Surgery for Stage II Prostate Cancer
NCT00765479 – Phase II/III – Currently Recruiting – Location: Chicago IL

Provenge (TM) for the Treatment of Hormone Sensitive Prostate Cancer (PROTECT)
NCT00779402 – Phase III – Not Recruiting – Location: various in USA

Prevention of Prostate Cancer With Dutasteride in Case of High Grade PIN Neoplasia
NCT00780754 – Phase III – Currently Recruiting – Location: Kaunas, Lithuania

Efficacy and Safety Study of Vandetanib (ZD 6474) in Combination With Bicalutamide Versus Bicalutamide Alone in Patients With Chemotherapy Naive Hormone Refractory Prostate Cancer.
NCT00757692 – Phase II – Not yet Recruiting – Location: Vancouver, Canada

A Multicenter Clinical Study of the Sonablate® 500 (SB-500) for the Treatment of Localized (T1c/T2a) Prostate Cancer With HIFU (SetPace)
NCT00770822 – Phase III – Currently Recruiting – Location: several in USA

MRI-Guided Biopsy of Recurrent Prostate Cancer After Radiotherapy
NCT00775866 – Phase n/a – Currently Recruiting – Location: Toronto, Canada

A Multicenter Clinical Study of the Sonablate® 500 (SB-500) for the Treatment of Locally Recurrent Prostate Cancer With HIFU (STAR)
NCT00772317 – Phase III – Currently Recruiting – Location: several in USA

Magnetic Resonance (MR) Spectroscopy in Localized Prostate Cancer
NCT00756392 – Phase III – Not yet Recruiting – Location: Edmonton, Canada

Bicalutamide and Deforolimus in Men With Prostate Cancer
NCT00777959 – Phase II – Currently Recruiting – Location: Sierra Vista AZ

Androgen Deprivation Therapy +/- Bevacizumab for PSA Recurrence of Prostate Cancer After Definitive Local Therapy
NCT00776594 – Phase II – Currently Recruiting – Location: Boston MA

PHA-739358 for Treatment of Hormone Refractory Prostate Cancer
NCT00766324– Phase II – Currently Recruiting – Location: Nerviano, Milano, Italy

Radiation Therapy and Hormone Therapy in Treating Patients With Prostate Cancer
NCT00769548 – Phase III – Not Recruiting – Location: San Francisco CA

Medical Nutrition Therapy or Standard Care in Treating Patients With Lung Cancer, Pancreatic Cancer, or Stage III or Stage IV Prostate Cancer
NCT00769652 – Phase n/a – Currently Recruiting – Location: New Brunswick NJ

Study of Effectiveness of IMC-A12 Antibody Combined With Hormone Therapy Prior to Surgery to Treat Prostate Cancer
NCT00769795 – Phase II – Currently Recruiting – Location: Seattle WA

Cholecalciferol and Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone Metastases
NCT00769990 – Phase I/II – Currently Recruiting – Location: Minneapolis MN

Combination of Serum Measurements of Molecular Biomarkers and Serum Protein Profiling Can be Used to Predict Which Patients Undergoing Prostatic Biopsy Will be Diagnosed With Cancer
NCT00773773 – Phase n/a – Currently Recruiting – Location: New York NY

A Study of V934/V935 in Cancer Patients With Selected Solid Tumors (Merck)
NCT00753415 – Phase I – Currently Recruiting – Location: Tampa FL and Philadelphia PA

Radical Prostatectomy and Perioperative Fluid Therapy
NCT00771966 – Phase IV – Currently Recruiting – Location: Copenhagen, Denmark

The AIM Study: Assessing the Impact of Margin Reduction
NCT00754000 – Phase n/a – Currently Recruiting – Location: several in USA

Prostate Active Surveillance Study (PASS)
NCT00756665 – Phase n/a – Currently Recruiting – Location: several in USA and Vancouver Canada

A Prospective Randomized Phase III Study Comparing Hormonal Therapy +/-Docetaxel (RisingPSA)
NCT00764166 – Phase III – Not Recruiting – Location: Paris, France

CMT-07-08: The PROstate Bed Evaluation Study
NCT00763152 – Phase n/a – Currently Recruiting – Location: Scottsdale AZ and St. Louis MO

 

 

Prostate Cancer Research Institute (PCRI)
 

Material provided by PCRI is intended for educational purposes for discussion with your physician and should not be considered as medical advice. Information and opinions expressed on this website are not an endorsement by PCRI for any treatment, product or service.