Each of the following sections contains many papers meant to inform you on the various aspects of prostate cancer. Most of the papers were originally published in the PCRI Insights newsletter, and have been converted to Web pages with key terms linked to the PCRI Glossary.

Some sections include references to additional articles that have been published in Insights with the volume and issue noted. You can download the issue in Adobe Acrobat (PDF) format by using the link provided. If you do not already have Adobe Reader® installed, Click here to get your free copy. If you have difficulty downloading the Insights issues or you would like to receive a printed copy of the issue, contact the PCRI Helpline by calling 310-743-2110 or sending an email to help@pcri.org

Many of these topics have been covered in PowerPoint Lectures. The slides are available for viewing.

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     BASICS OF PROSTATE CANCER

Genetics

• Genetic Theories
  

Nutrition

• Can Natural Dietary Supplements Really Impact Prostate Cancer? • Jacek Pinski, MD, PhD
• also en Español
• Advances in Holistic PC Chemoprevention and Treatment • Aaron Katz, M.D.
• Pomegranates and Prostate Health: A Research Report • Mark Dreher, Ph.D.
• The Linkage Between Obesity and Prostate Cancer • David Heber, MD, PhD, FACP, FACN
• Some Basic Facts on PC (Testing and Nutrition)
• Can Diet Really Control Prostate Cancer? • Mark Scholz, MD and Ralph Blum
• Nutritional Recommendations for Active Prostate Cancer • Stephen B. Strum, MD
• General Comments on Diet
   

     UNDIAGNOSED

Pre-Clinical Phase

• The PCRI Views Regarding Testing for Prostate Cancer
• What Every Doctor Who Treats Male Patients Should Know • Stephen B. Strum, MD, FACP and Donna Pogliano
• Using PSA Intelligently to Manage Prostate Cancer, Part 1 • Jonathan McDermed, PharmD
  • Part 2
• PCA3: A Genetic Marker of Prostate Cancer • Alejandra B.Torres and Leonard S.Marks, MD
• PSA Doubling Time
• PIN
• 5 Region Biopsy
  

     NEWLY DIAGNOSED

Self-Empowerment

• Newly-Diagnosed - the Very Basics • Mark Scholz, MD and Richard Lam, MD
• Finding the Best Treatment • Mark Scholz, MD
• E-Empowerment • Arthur Lurvey, MD
• A Medical Miranda for the PC Patient
• What We Should Have Learned about PC in the Last 10 Years. - Stephen B. Strum, MD, FACP
  • Part 1 – Prostate Cancer Landscape and the Potential for Prevention
  • Part 2 – Exploring the Lessons from the Prostate Cancer Prevention Trial
  • Part 3 – The Use the PSA and Derivative Tools in Diagnosis and Staging
• The PCRI Glossary: A Tool for Learning About PC
• Who's At Risk for What? • Mark Scholz, MD
  • Laboratory Tests Defined
• Participating in a Prostate Cancer Clinical Trial • Stanley A. Brosman, MD

Risk Assessment and Algorithms

• A Strategy Of Success in the Treatment of Prostate Cancer • Stephen B. Strum MD
• Newly Diagnosed PC: Evaluating the Options (Part 1 - Introduction) • Mark Scholz, MD
  • also en Español
• Using Nomograms to Predict Pathological Stage and Treatment Outcome for Patients with Prostate Cancer • Glenn Tisman, MD
• Partin Tables
• Narayan Tables
• Bluestein Tables
• Risk Assessment Patient Worksheet
• Prostate Assistant Software
• Prostate Cancer Tools Software
• Prostate Cancer Tools II: Software to Aid in Patient Counseling • Glenn Tisman, MD - v4.2, PDF
• PC Digest - v1.1, PDF

Staging

• Is There a Correct Way to Treat PC?
• The Clinical Stage: Its Definition and Importance in Prostate Cancer • Harry Pinchot and Stephen B. Strum MD
• Understanding Your Biopsy Results
• The Gleason Score: Prostate Cancer Aggressiveness On Biopsy • Gerry J. O’Dowd et al
• Gleason Grade Migration: Changes in Prostate Cancer Grade in the Contemporary Era • Daniel J. Luthringer, MD and Mitchell Gross, MD
• Does Finasteride Alter the Pathology of the Prostate and Cancer Grading? • David G. Bostwick MD
• Ploidy Analysis
• Staging Suggestions
• D'Amico Papers

Diagnostic Scanning

• Color Doppler and Tissue Harmonic Ultrasound • Duke Bahn, MD
• Magnetic Resonance Anatomic and Spectroscopic Imaging of Prostate Cancer – Current Status • John Kurhanewicz, Christopher K. Sotto and Fergus Coakley
• Endorectal MRI with spectroscopy - 2000 • UCSF Prostate Cancer MRI/MRSI Group
• MRI in Prostate Cancer • Jelle Barentsz, M.D., Ph.D
• Update on ProstaScint: CT and MRI Fusion as Diagnostic Tools • Samuel Kipper, MD
• Ferumoxtran-10 (Combidex): An Important New Prostate Cancer Staging Tool • Maha Torabi, MD and Mukesh G. Harisinghani, MD
• Bone Scan
   

     LOCAL THERAPY

Treatment for Localized Disease

• Newly Diagnosed PC: Evaluating the Options (Part 2 - for lower risk patients) • Mark Scholz, MD
  • also en Español
    1. Deferred therapy (previously known as watchful waiting)
    2. Androgen deprivation therapy (ADT)
    3. Brachytherapy (Seeds)
    4. Surgery (radical prostatectomy)
    5. Intensity modulated radiation therapy (IMRT)
    6. Cryotherapy (Cryo)
    7. High Dose Radiation (HDR) Monotherapy
     
• Active Surveillance For Favorable Risk Prostate Cancer:
  What Are The Results, and How Safe Is It? - Laurence Klotz, MD et al.
• Active Surveillance with High Resolution Color-Doppler Transrectal Ultrasound Monitoring • Duke Bahn, MD, Mark Scholz, MD, and Richard Lam, MD
• Radical Prostatectomy • Stanley Brosman, MD
• Nerve Sparing Robotic Prostatectomy • Ashutosh Tewari, MD, Mani Menon, MD, et al
• Nerve Sparing Robotic Prostatectomy -Update • Ashutosh Tewari, MD
• Prostate Seed Implantation for Prostate Cancer • Peter Grimm, DO, et al.
• High Dose Rate (HDR) Brachytherapy • D. Jeffrey Demanes MD, FACRO, FACR
• Temporary Seed Implant with High Dose Rate Brachytherapy (HDR) • Glenn Gejerman, MD
• Salvage High Dose Rate Brachytherapy After Radiation • Paul Y. Song, M.D.
• Intensity Modulated Radiation Therapy (IMRT) • Lisa Chaiken, MD, et al.
• Cryoablation of the Prostate • Duke K. Bahn, MD, et al.  

Novel Therapies

• Has the Time Come for Focal Therapy of Prostate Cancer? • Martin J Weissman, M.D.
• Transrectal High Intensity Focused Ultrasound: The Next Generation? • Douglas O. Chinn, MD
• CancerCryo-Immunotherapy: A Battle Between the Immune System and Cancer • Haakon Ragde, MD and Duke K. Bahn, MD
  

     SYSTEMIC THERAPY

• Newly Diagnosed PC: Evaluating the Options (Part 3 - for higher risk patients) • Mark Scholz, MD
  • also en Español

Androgen Deprivation Therapy

• Hormone Therapy in PC
• Androgen deprivation therapy - v2.4, PDF
• Clinical flare
• Proscar in PC
• Casodex (vs. Flutamide) Overview
• Neoadjuvant Therapy of PC
• Adjuvant Androgen Withdrawal • Glenn Tisman, MD
• Preventing and Treating the Side Effects of Testosterone Deprivation Therapy - Brad Guess PA-C
• Anti-androgen Monotherapy • Prostate Oncology Specialists
• Intermittent Androgen Deprivation • Stephen B. Strum, MD
  • Understanding the Endocrinology of PC
• Importance of Concordance in PC Management
• High Dose Ketoconazole Plus Hydrocortisone (HDK+ HC)
• Anti-androgen Withdrawal Response (AAWR)
• Beating Prostate Cancer with Hormonal Therapy • Charles Myers, MD
• Androgen Resistance (Part 1) • Charles Myers, MD
• Androgen Resistance (Part 2)
• Androgen Resistance (Part 3)
   

     ANDROGEN INDEPENDENT PC

• Listening to the Biology of PC • Stephen Strum, MD
  • also en Español
• Hormone-Refractory Prostate Cancer: A Continuum of Diseases and Options • Oliver Sartor, MD
• Chemotherapy in Prostate Cancer • Richard Lam, MD
• Chemotherapy for Prostate Cancer: "Why Bother?" • Brad Guess, PA-C
• Dealing with Taxotere Side Effects • Richard Lam, MD
• Important Principles in Chemotherapy (AIPC) • Stephen Strum, MD
• Cytoxan
• Logothetis Protocol
• How do you Treat PC that has Progressed on Primary ADT?
• Part II of Above
   

     HIGH RISK PC

• Bone -Targeted Therapy for Advanced Prostate Cancer • Oliver Sartor, MD
• Newer Concepts in the Treatment of Hormone-Refractory Prostate Cancer with Bone Metastases • Oliver Sartor, MD
• Bagley Regimen • Stephen B. Strum, MD
• Servadio regimen of DES + Cytoxan + 5FU - v1.1, PDF
• Review of Bolla Paper
• Small Cell PC
• Bone integrity relation to PC activity: extent of disease vs survival - v2.2, PDF

Novel Therapies

• Immunotherapy And Advanced Prostate Cancer - By William Cavanagh
• The Abscopal Effect - Using Cancer Against Itself - By William Cavanagh
• Introduction to Monoclonal Antibodies
• Dendritic Cells - Key to PC Immunotherapy • Frank Valone, MD - v4.4, PDF
• Update on Provenge Trials - Sept 2005
• Update on Provenge Trials - Nov 2006
   

     SIDE EFFECTS

Treatment Side Effects

• Preventing and Treating the Side Effects of Testosterone Deprivation Therapy - Brad Guess PA-C
• Dealing with Taxotere Side Effects - Richard Lam, MD
• Anemia of Androgen Deprivation
• Androgen Deprivation Syndrome (ADS) • Stephen B. Strum, MD
• The Treatment of Erectile Dysfunction • Stephen M.Auerbach, MD
• Incontinence Treatment Options for Post-Prostatectomy • Gary E. Leach, MD
• Important Principles in Chemotherapy (AIPC) • Stephen Strum, MD
• Photoselective Vaporization Prostatectomy: A Palliative Treatment Option for Men with Urinary Obstruction Secondary to Prostate Cancer • Mahmood A. Hai MD, FACS

Bone Integrity

• Biphosphonate Therapy Update
• Biphosphonates
• Bone Integrity - concept introduced - v1.1, PDF
• Bone Integrity - in depth review • Stephen Strum, MD
• Association between bone formation and destruction - v2.2, PDF
• Ipriflavone: Synthetic soy derivative improves bone integrity - v2.4, PDF

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Material provided by PCRI is intended for educational purposes for discussion with your physician and should not be considered as medical advice. Information and opinions expressed on this website are not an endorsement by PCRI for any treatment, product or service.